The airway epithelium plays a central role in the pathogenesis of asthma and COPD, acting not only as a physical barrier but also as an active regulator of innate immune responses. Epithelial-derived alarmins, including TSLP and IL-33, contribute to airway inflammation, while impaired antiviral interferon responses may increase susceptibility to virus-induced exacerbations.
In this seminar, we will discuss how epithelial immune dysregulation contributes to chronic airway disease, highlighting the interplay between inflammatory and antiviral pathways. We will then present ongoing translational research in the group, aimed at improving our understanding of disease mechanisms in asthma and COPD. This will include the RECONSTRUCT study where we could demonstrate that asthma mainstay treatment affects antiviral pathways in patients with asthma dependent on their underlying inflammation.
When: Monday, November 16th at 10:00
Where: BMC A10, Segerfalksalen
Stay afterwards for fika and discussion provided by Miltenyi Biotec.
